Predictive analytics for intelligent biopharma production

Cytomos® believes in affordable biopharmaceutical therapies serving the world's growing population made possible by intelligent bioprocessing

Intelligent bioprocessing requires novel, integrated and scalable process analytical technologies

Cytomos® Dielectric Spectroscopy (CDS™) is a full-stack, single-cell resolution analysis technology, spanning integrated sensors through to machine learning enhanced algorithms

CDS™ | The Dark Side of Spectroscopy

Different wavelengths of light refract at different angles

Different electric field frequencies behave similarly

CDS™ applies an electric field across single cells in suspension measuring 16,000+ frequencies per cell

Different interfaces in and around each cell refract different frequencies, generating a unique CDS™ spectrum per cell

A platform for evaluation & collaboration

Unbiased

Label-free spectroscopy

Predictive analysis potential

Scalable

Single-cell resolution of

cells flowing in suspension

Integrated

Microelectronic sensors can be implemented across production

Try CDS™ in your lab

Identifying cells without labels

Example: Identifying lymphocyte sub-populations within a mixture

(a) Scatterplot view after dimensional reduction

(b) CDS™ spectroscopic output

T-cell lymphoblasts (MOLT-4) identified from a 1:1 mixture with B-cell lymphoblasts (MM1.s) via different CDS™ spectra, confirmed with MM1.s only sample. Each dot in Figure (a) represents a cell identified from an individual CDS™ spectrum. Average spectrum for each gate shown in Figure (b). 12,144 cells measured in 15 mins.

Monitoring manufacturing drift

Example: Identifying subtle differences between T-cell lines

(a) Scatterplot view after dimensional reduction

(b) CDS™ spectroscopic output

T-cell lymphoblasts (MOLT-4 vs Jurkat) differentiated through their intrinsic CDS™ spectra. Each dot in Figure (a) represents a cell identified from an individual CDS™ spectrum. Average spectrum for each identified population shown in Figure (b). 4,103 cells measured in 15 mins.

Creativity | Collaboration | Delivery

Cytomos® has a strong multi-disciplinary team of biological scientists and engineers dedicated to providing our partners with relevant and actionable information from their bioprocesses

Find out more

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Cytomos Limited

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Edinburgh EH3 7PE

Scotland