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Predictive analytics for intelligent biopharma production

Cytomos® believes in affordable biopharmaceutical therapies serving the world's growing population made possible by intelligent bioprocessing

Intelligent bioprocessing requires novel, integrated and scalable process analytical technologies

Cytomos® Dielectric Spectroscopy (CDS™) is a full-stack, single-cell resolution analysis technology, spanning integrated sensors through to machine learning enhanced algorithms 

CDS™ | The Dark Side of Spectroscopy 

Different wavelengths of light refract at different angles
Different electric field frequencies behave similarly 
CDS™ applies an electric field across single cells in suspension measuring 16,000+ frequencies per cell
Different interfaces in and around each cell refract different frequencies, generating a unique CDS™ spectrum per cell

A platform for evaluation & collaboration

Unbiased
Label-free spectroscopy
Predictive analysis potential
Scalable
Single-cell resolution of
cells flowing in suspension
Integrated
Microelectronic sensors can be implemented across production

Identifying cells without labels

Example: Identifying lymphocyte sub-populations within a mixture

(a) Scatterplot view after dimensional reduction
(b) CDS™ spectroscopic output

T-cell lymphoblasts (MOLT-4) identified from a 1:1 mixture with B-cell lymphoblasts (MM1.s) via different CDS™ spectra, confirmed with MM1.s only sample. Each dot in Figure (a) represents a cell identified from an individual CDS™ spectrum. Average spectrum for each gate shown in Figure (b). 12,144 cells measured in 15 mins. 

Monitoring manufacturing drift

Example: Identifying subtle differences between T-cell lines

(a) Scatterplot view after dimensional reduction
(b) CDS™ spectroscopic output

T-cell lymphoblasts (MOLT-4 vs Jurkat) differentiated through their intrinsic CDS™ spectra. Each dot in Figure (a) represents a cell identified from an individual CDS™ spectrum. Average spectrum for each identified population shown in Figure (b). 4,103 cells measured in 15 mins. 

Creativity | Collaboration | Delivery

Cytomos® has a strong multi-disciplinary team of biological scientists and engineers dedicated to providing our partners with relevant and actionable information from their bioprocesses

Cytomos Limited

13 Melville Street

Edinburgh EH3 7PE

Scotland

Registered in Scotland SC401416

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© Cytomos Limited 2021