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Predictive analytics for intelligent biopharma production

Cytomos® believes in affordable biopharmaceutical therapies serving the world's growing population made possible by intelligent bioprocessing

Intelligent bioprocessing requires novel, integrated and scalable process analytical technologies

Cytomos® Dielectric Spectroscopy (CDS™) is a full-stack, single-cell resolution analysis technology, spanning integrated sensors through to machine learning enhanced algorithms 

CDS™ | The Dark Side of Spectroscopy 

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Different wavelengths of light refract at different angles
Different electric field frequencies behave similarly 
CDS™ applies an electric field across single cells in suspension measuring 16,000+ frequencies per cell
Different interfaces in and around each cell refract different frequencies, generating a unique CDS™ spectrum per cell

A platform for evaluation & collaboration

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Unbiased
Label-free spectroscopy
Predictive analysis potential
Scalable
Single-cell resolution of
cells flowing in suspension
Integrated
Microelectronic sensors can be implemented across production

Identifying cells without labels

Example: Identifying lymphocyte sub-populations within a mixture

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(a) Scatterplot view after dimensional reduction
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(b) CDS™ spectroscopic output

T-cell lymphoblasts (MOLT-4) identified from a 1:1 mixture with B-cell lymphoblasts (MM1.s) via different CDS™ spectra, confirmed with MM1.s only sample. Each dot in Figure (a) represents a cell identified from an individual CDS™ spectrum. Average spectrum for each gate shown in Figure (b). 12,144 cells measured in 15 mins. 

Monitoring manufacturing drift

Example: Identifying subtle differences between T-cell lines

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(a) Scatterplot view after dimensional reduction
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(b) CDS™ spectroscopic output

T-cell lymphoblasts (MOLT-4 vs Jurkat) differentiated through their intrinsic CDS™ spectra. Each dot in Figure (a) represents a cell identified from an individual CDS™ spectrum. Average spectrum for each identified population shown in Figure (b). 4,103 cells measured in 15 mins. 

Creativity | Collaboration | Delivery

Cytomos® has a strong multi-disciplinary team of biological scientists and engineers dedicated to providing our partners with relevant and actionable information from their bioprocesses
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Registered in Scotland SC401416

Cytomos Limited

13 Melville Street

Edinburgh EH3 7PE

Scotland

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